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Arachidonylcyclopropylamide

Cannabinoid receptor ligand
 
BML-FA031-0010 10 mg 62.00 USD
 
BML-FA031-0050 50 mg 239.00 USD
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Replaces Prod. #: ALX-340-054

High affinity selective agonist for the cannbinoid CB1 receptor (Ki= 2.2 nM; CB2 receptor Ki= 0.7 µM). Inhibits forskolin-induced cAMP accumulation, increases binding of GTPγS to cerebellar membranes, inhibits electrically-evoked contractions of mouse vas deferens and production of hypothermia in mice. Active in vivo.

Product Specification

Formula:C23H37NO
 
MW:343.6
 
CAS:229021-64-1
 
Purity:≥98% (TLC)
 
Appearance:Pale yellow oil.
 
Solubility:Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) or dimethyl formamide. 1mg/ml soluble in a 1:1 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from air.
 
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Product Literature References

The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice: H. Shafaroodi, et al.; Neuropharmacology 47, 390 (2004), Abstract;
Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors: A. Franklin & N. Stella; Eur. J. Pharmacol. 474, 195 (2003), Abstract;
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1): C.J. Hillard, et al.; J. Pharmacol. Exp. Ther. 289, 1427 (1999), Abstract;

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