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2-Arachidonoylglycerol

Cannabinoid receptor ligand
 
BML-FA028-0005 5 mg 120.00 USD
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Replaces Prod. #: ALX-340-036

Endogenous ligand for the CB1 receptor (CB1: Ki=58.3nM); CB2: Ki>3µM) present in high levels in the CNS.

Product Specification

Alternative Name:2-AG
 
Formula:C23H38O4
 
MW:378.6
 
CAS:53847-30-6
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Oil.
 
Solubility:Soluble in DMSO or 100% ethanol.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -70°C. Stock solutions are stable for up to 3 months when stored at -70°C under an atmosphere of nitrogen or argon.
 
Handling:Protect from light and oxygen. Keep under inert gas.
 
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Product Literature References

2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells: M. Gokoh, et al.; Biochem. J. 386, 583 (2005), Abstract; Full Text
A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells: K. Nithipatikom, et al.; BBRC 332, 1028 (2005), Abstract;
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus: J.K. Makara, et al.; Nat. Neurosci. 8, 1139 (2005), Abstract;
2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells: S. Kishimoto, et al.; J. Biochem. 135, 517 (2004), Abstract;
2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion: K. Nithipatikom, et al.; Cancer Res. 64, 8826 (2004), Abstract; Full Text
New perspectives in the studies on endocannabinoid and cannabis: 2-arachidonoylglycerol as a possible novel mediator of inflammation: T. Sugiura, et al.; J. Pharmacol. Sci. 96, 367 (2004), Abstract; Full Text
The endogenous cannabinoid 2-arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein: G.J. Maestroni; FASEB J. 18, 1914 (2004), Abstract; Full Text
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain: T. Bisogno, et al.; J. Cell Biol. 163, 463 (2003), Abstract;
The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors: T. Bisogno, et al.; Eur. J. Biochem. 268, 1982 (2001), Abstract;
Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors: S.K. Goparaju, et al.; Biochem. Pharmacol. 57, 417 (1999), Abstract;
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds: T. Sugiura, et al.; J. Biol. Chem. 274, 2794 (1999), Abstract; Full Text
Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments: V. Di Marzo, et al.; Lipids 34, S319 (1999), (Review), Abstract;
2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanis: S. Kondo, et al.; FEBS Lett. 429, 152 (1998), Abstract;
An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity: S. Ben-Shabat, et al.; J. Pharmacol. 353, 23 (1998), Abstract;
A second endogenous cannabinoid that modulates long-term potentiation: N. Stella, et al.; Nature 388, 773 (1997), Abstract;

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