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5,8,11,14-Eicosatetraynoic acid

Arachidonic acid uptake inhibitor
BML-ET004-0020 20 mg 77.00 USD
BML-ET004-0100 100 mg 322.00 USD
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Replaces Prod. #: ALX-340-010

Inhibits arachidonic acid uptake. Inhibits cyclooxygenase (ID50=8 µM) and all lipoxygenases (ID50=10, 0.3, and 0.2 µM for 5-, 12- and 15-LO respectively) in whole cells. Inhibits PLA2 and cytochrome P-450. Modulates Ca2+ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells. PPAR agonist.

Product Specification

Alternative Name:ETYA
Purity:≥98% (TLC)
Appearance:Off-white solid.
Solubility:Soluble in 100% ethanol, methanol, DMSO, acetone or acetonitrile.
Long Term Storage:+4°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Make solutions fresh daily.
Handling:Protect from light and oxygen.
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Product Literature References

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One 6, e25395 (2011), Abstract; Full Text
Activation of TRPA1 by farnesyl thiosalicylic acid: M. Maher, et al.; Mol. Pharmacol. 73, 1225 (2008), Abstract;
Effects of 5,8,11,14-eicosatetraynoic acid on thapsigargin-induced calcium entry, and intracellular pH in thyroid FRTL-5 cells: E. Ekokoski & K. Tornquist; Biochim. Biophys. Acta 1223, 274 (1994), Abstract;
Inhibition of U937 eicosanoid and DNA synthesis by 5,8,11,14- eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism and its partial reversal by leukotriene C4: F. Ondrey, et al.; Cancer Res. 49, 1138 (1989), Abstract;
Incorporation of 5,8,11,14-eicosatetraynoic acid (ETYA) into cell lipids: competition with arachidonic acid for esterification: A.S. Taylor, et al.; Prostaglandins 29, 449 (1985), Abstract;
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostaglandins Leukot. Med. 13, 53 (1984), Abstract;
The mechanism of inactivation of lipoxygenases by acetylenic fatty acids: H. Kühn, et al.; Eur. J. Biochem. 139, 577 (1984), Abstract;
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets: J.R. Falck, et al.; BBRC 114, 743 (1983), Abstract;
Phospholipase A2-induced rat mast cell secretion. Role of arachidonic acid metabolites: E.Y. Chi, et al.; Lab. Invest. 47, 579 (1982), Abstract;
Evidence for inhibition of leukotriene A4 synthesis by 5,8,11,14-eicosatetraynoic acid in guinea pig polymorphonuclear leukocytes: G.M. Bokoch & P.W. Reed; J. Biol. Chem. 256, 4156 (1981), Abstract; Full Text
An inhibitor of arachidonic acid metabolism stimulates luteinizing hormone (LH) release from cultured pituitary cells: P.M. Conn, et al.; Prostaglandins 19, 873 (1980), Abstract;
The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism: L.D. Tobias & J.G. Hamilton; Lipids 14, 181 (1979), Abstract;
Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthetase: D.T. Downing, et al.; Biochim. Biophys. Acta 280, 343 (1972), Abstract;

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