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5,8,11-Eicosatriynoic acid

Lipoxygenase inhibitor
 
BML-ET003-0001 1 mg 83.00 USD
 
BML-ET003-0010 10 mg 596.00 USD
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Replaces Prod. #: ALX-340-009

Inhibits lipoxygenases (ID50=3, 20 and 20µM for 5-, 12- and 15-LO respectively) selectively over cyclooxygenase (ID50=50µM) in whole cells. Also inhibits hepatic glutathione S-transferase and leukotriene C4 biosynthesis.

Product Specification

Alternative Name:ETI
 
Formula:C20H28O2
 
MW:300.4
 
CAS:13488-22-7
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in ethanol (25mg/ml), DMSO (25mg/ml) or dimethyl formamide.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:+4°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light and oxygen. Keep under inert gas.
 
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Product Literature References

Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death: R.G. Fred, et al.; Mol. Cell. Endocrinol. 414, 53 (2015), Application(s): Cell culture , Abstract;
Inhibition of mammalian hepatic glutathione S-transferases by acetylenic fatty acids: K. Datta & A.P. Kulkarni; Toxicol. Lett. 73, 157 (1994), Abstract;
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostaglandins Leukot. Med. 13, 53 (1984), Abstract;
Inhibition of leukotriene C and leukotriene D biosynthesis: L. Orning & S. Hammarstrom; J. Biol. Chem. 255, 8023 (1980), Abstract;
Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid: S. Hammarstrom; Biochim. Biophys. Acta 487, 517 (1977), Abstract;

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