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SU11652

VEGFR inhibitor
 
BML-EI408-0001 1 mg 191.00 USD
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Potent, ATP-competitive and cell permeable inhibitor of tyrosine kinases (VEGF-R2 IC50=27nM, PDGF-Rβ IC50=3nM). Also inhibits wild-type and all mutant forms of Kit in mast cells (IC50's=10 to 100nM) resulting in cell cycle arrest and apoptosis. Su11652 was also shown to induce autophagy in MCF-7 cells.

Product Specification

Alternative Name:5-[5-Chloro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide
 
Formula:C22H27ClN4O2
 
MW:414.9
 
CAS:326914-10-7
 
Purity:≥98% (HPLC)
 
Appearance:Orange solid.
 
Solubility:Soluble in DMSO (>25 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt whenstored at -20°C.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-EI408 Structure
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BML-EI408 Structure

Product Literature References

Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux: T. Farkas, et al.; Autophagy 5, 1018 (2009), Abstract; Full Text
Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase: L. Sun, et al.; J. Med. Chem. 46, 1116 (2003), Abstract;
Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors: A.T. Liao, et al.; Blood 100, 585 (2002), Abstract; Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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