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Src I1

Inhibitor of Src kinase and p56lck tyrosine kinase
BML-EI398-0025 25 mg 318.00 USD
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Potent, dual site (ATP domain and substrate-binding domain) Src and Lck kinase inhibitor (IC50=44 and 88nM respectively). VEGFR2 IC50=0.32μM; c-fms IC50=30μM.

Product Specification

Alternative Name:6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
Purity:≥98% (HPLC)
Appearance:Off-white solid.
Solubility:Soluble in DMSO (5mg/ml).
Long Term Storage:Ambient
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
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Product Literature References

c-Src tyrosine kinase mediates high glucose-induced endothelin-1 expression: S.A. Manea, et al.; Int. J. Biochem. Cell Biol. 75, 123 (2016), Application(s): Cell culture, Abstract;
The selectivity of protein kinase inhibitors: a further update: J. Bain, et al.; Biochem. J. 408, 297 (2007), Abstract;
Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines: G. Tian, et al.; Biochemistry 40, 7084 (2001), Abstract;

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