SMER28

Small molecule inducer of autophagy important for neurodegenerative disease research.



BML-EI397-0005	5 mg	72.00 USD

BML-EI397-0025	25 mg	288.00 USD

Chemical inducer of autophagy which acts via an mTOR-independent mechanism. It increased autophagosome synthesis and enhanced the clearance of model autophagy substrates such as A53T α-synuclein and mutant huntingtin fragments. It reduced Aβ peptide and AAP-CTF levels in an Alzheimers model and attenuated mutant huntingtin-fragment toxicity in Huntington’s disease models, suggesting therapeutic potential.

Product Specification

Alternative Name:	6-Bromo-4-allylaminoquinazoline

Formula:	C₁₁H₁₀BrN₃

MW:	264.1

Purity:	98% (TLC)

Appearance:	Off-white solid.

CAS:	307538-42-7

Solubility:	Soluble in DMSO (8mg/ml) or 100% ethanol (2mg/ml).

Long Term Storage:	-20°C

Use/Stability:	Store solutions at -20°C for up to 3 months.

Hazard:	HARMFUL.

Background / Technical Information:	Please click here for the comprehensive product data sheet.

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Product Literature References

A small-molecule enhancer of autophagy decreases levels of Aß and APP-CTF via Atg5-dependent autophagy pathway: Y. Tian, V. Bustos, M. Flajolet, and P. Greengard; FASEB J. Epub ahead of print, PMID: 21368103 (2011), Abstract;

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies: D. Shen, et al.; Cell Biochem. Biophys. Epub ahead of print, (2011), Abstract;

Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases: M. Renna, et al.; J. Biol. Chem. 285, 11061 (2010), Abstract;

Small molecules enhance autophagy and reduce toxicity in Huntington’s disease models: S. Sarkar, et al.; Nat. Chem. Biol. 3, 331 (2007), Abstract;