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SMER28

Small molecule inducer of autophagy important for neurodegenerative disease research.
 
BML-EI397-0005 5 mg 85.00 USD
 
BML-EI397-0025 25 mg 334.00 USD
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Chemical inducer of autophagy which acts via an mTOR-independent mechanism. It increased autophagosome synthesis and enhanced the clearance of model autophagy substrates such as A53T α-synuclein and mutant huntingtin fragments. It reduced Aβ peptide and AAP-CTF levels in an Alzheimers model and attenuated mutant huntingtin-fragment toxicity in Huntington’s disease models, suggesting therapeutic potential.

Product Specification

Alternative Name:6-Bromo-4-allylaminoquinazoline
 
Formula:C11H10BrN3
 
MW:264.1
 
Source:Synthetic.
 
CAS:307538-42-7
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (8mg/ml) or 100% ethanol (2mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
BML-EI397
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BML-EI397

Product Literature References

A small-molecule enhancer of autophagy decreases levels of Aß and APP-CTF via Atg5-dependent autophagy pathway: Y. Tian, et al.; FASEB J. 25, 1934 (2011), Abstract;
Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies: D. Shen, et al.; Cell Biochem. Biophys. 60, 173 (2011), Abstract; Full Text
Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases: M. Renna, et al.; J. Biol. Chem. 285, 11061 (2010), Abstract;
Small molecules enhance autophagy and reduce toxicity in Huntington’s disease models: S. Sarkar, et al.; Nat. Chem. Biol. 3, 331 (2007), Abstract;

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