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CCG-1423

Rho inhibitor
 
BML-EI394-0010 10 mg 69.00 USD
 
BML-EI394-0050 50 mg 279.00 USD
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Cell permeable inhibitor of RhoA- and RhoC-mediated signaling. Inhibits LPA-induced DNA synthesis in PC-3 prostate cancer cell lines (<1µM) and inhibits the growth of RhoC-overexpressing melanoma cell lines (A375M2 and SK-Mel-147) at nanomolar concentrations.

Product Specification

Alternative Name:N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide
 
Formula:C18H13ClF6N2O3
 
MW:454.8
 
CAS:285986-88-1
 
Purity:≥97% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (10mg/ml) or 100% ethanol (9mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
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Product Literature References

CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling: C.R. Evelyn, et al.; Mol. Cancer Ther. 6, 2249 (2007), Abstract;

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