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JZL-184

Monoacylglycerol lipase inhibitor
 
BML-EI391-0010 10 mg 72.00 USD
 
BML-EI391-0050 50 mg 288.00 USD
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Potent, selective and irreversible inhibitor of MAG lipase (IC50=8nM vs 4µM for FAAH). JZL-184-treated mice displayed a number of CB1-dependent behavioral effects including analgesia, hypothermia and hypomotility as well as increased levels of 2-arachidonoylglycerol in the brain ( approx. 8-fold, with no effect on anandamide levels). JZL-184 produces a rapid and sustained blockade of brain 2-AG hydrolase activity in mice. It blocks neuropathic pain and enhances retrograde endocannabinoid signaling.

Product Specification

Alternative Name:4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate
 
Formula:C27H24N2O9
 
MW:520.5
 
Source:Synthetic.
 
CAS:1101854-58-3
 
Purity:≥98% (TLC)
 
Identity:Determined by NMR.
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling: B. Pan, et al.; J. Pharmacol. Exp. Ther. 331, 591 (2009), Abstract;
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain: S.G. Kinsey, et al.; J. Pharmacol. Exp. Ther. 330, 902 (2009), Abstract;
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects: J.Z. Long, et al.; Nat. Chem. Biol. 5, 37 (2009), Abstract;

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