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AS-041164

PI3 kinase inhibitor
 
BML-EI390-0010 10 mg 76.00 USD
 
BML-EI390-0050 50 mg 302.00 USD
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A selective PI 3-Kγ isoform inhibitor (IC50 = 0.24, 1.45, 0.07 and 1.70μM for α, β, γ and δ isoforms respectively). Blocks RANTES-induced neutrophil migration and displays anti-inflammatory activity in various in vivo rodent models.

Product Specification

Alternative Name:NSC31098, 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione
 
Formula:C11H7NO4S
 
MW:249.2
 
CAS:6318-41-8
 
Purity:≥98% (TLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (25mg/mL). For in vivo administration this compound was suspended in 0.5% carboxymethylcellulose/0.25% Tween 20 as a vehicle.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment: C. Ferrandi, et al.; J. Pharmacol. Exp. Ther. 322, 923 (2007), Abstract;

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