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CaM kinase kinase inhibitor
BML-EI389-0005 5 mg 89.00 USD
BML-EI389-0025 25 mg 343.00 USD
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Replaces Prod. #: ALX-270-477

STO-609 is a specific CaM kinase kinase (CaM-KK) inhibitor. Ki=0.2μM and 0.04μM for α and β isotypes respectively. Demonstrates >80-fold selectivity for CAM-KK over CaMK1, CaMK2, CaMK4, MLCK, PKA, PKC, and p42 MAPK. Concentrations up to 10μg/ml do not affect cellular viability. It is a tool for exploring the role of the CaM-KK pathway in various physiological processes.

Product Specification

Alternative Name:7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, acetate salt
Purity:≥98% (HPLC)
Appearance:Yellow solid.
Solubility:Soluble in DMSO (10mg/ml).
Long Term Storage:Ambient
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
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Product Literature References

Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels: S.V. Jabba, et al.; J. Pharmacol. Exp. Ther. 332, 698 (2010), Abstract;
Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle: N. Iwanaka, et al.; J. Appl. Physiol. 108, 274 (2010), Abstract;
STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase: H. Tokumitsu, et al.; J. Biol. Chem. 277, 15813 (2002), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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