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BML-277

Chk inhibitor
 
BML-EI388-0010 10 mg 111.00 USD
 
BML-EI388-0050 50 mg 445.00 USD
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BML-277 is a highly selective inhibitor of Chk2 (IC50=15nM). It displays potent radioprotective activity and prevents apoptosis of human T cells subjected to ionizing radiation (EC50= 3-7.6µM). Useful tool for dissecting the role of Chk2 in cellular signaling.

Product Specification

Alternative Name:Chk2 Inhibitor II
 
Formula:C20H14ClN3O2
 
MW:363.8
 
CAS:516480-79-8
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (20mg/ml) or ethanol (20mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
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Product Literature References

Dual roles of ERK1/2 in cellular senescence induced by excess thymidine in HeLa cells: I. Kudo, et al.; Exp. Cell. Res. 16, 30205 (2016), Application(s): Cell culture, cervical tumor cells, Abstract;
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage: Y. Pereg, et al.; Mol. Cell. Biol. 26, 6819 (2006), Abstract; Full Text
Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles: K.L. Arienti, et al. ; J. Med. Chem. 48, 1873 (2005), Abstract;

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