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DAPH

EGFR inhibitor
 
BML-EI386-0005 5 mg 166.00 USD
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DAPH abolishes or greatly reduces previously existing fully formed β-amyloid (1-42) fibrils and eliminates β-amyloid (1-42) peptide neurotoxicity. Also inhibits EGFR kinase. IC50 for inhibition of β-sheet content of aggregated β-amyloid (1-42) is 4.5µM.

Product Specification

Alternative Name:4,5-Dianilinophthalimide, CGP-52411
 
Formula:C20H15N3O2
 
MW:329.4
 
CAS:145915-58-8
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:Orange solid.
 
Solubility:Soluble in DMSO (25mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
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Product Literature References

Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs: H. Wang, et al.; Proc. Natl. Acad. Sci. USA 105, 7159 (2008), Abstract; Full Text
Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule: B. J. Blanchard, et al.; Proc. Natl. Acad. Sci. USA 101, 14326 (2004), Abstract; Full Text
Transforming growth factor-alpha acting at the epidermal growth factor receptor reduces infarct volume after permanent middle cerebral artery occlusion in rats: C. Justicia & A. M. Planas; J. Cereb. Blood Flow. Metab. 19, 128 (1999), Abstract;

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