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ZM-323881

VEGFR inhibitor
 
BML-EI385-0001 1 mg 78.00 USD
 
BML-EI385-0005 5 mg 281.00 USD
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Potent and selective inhibitor of the kinase activity of the human vascular endothelial growth factor receptor 2 (VEGFR2/KDR). Selectively inhibits VEGFR2 over VEGFR1 and other receptor tyrosine kinases with an IC50 = 2nM. Useful tool for exploring the biology of VEGFR receptors.

Product Specification

Alternative Name:5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methyl phenol
 
Formula:C22H18FN3O2
 
MW:375.4
 
Source:Synthetic.
 
CAS:193001-14-8
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (3 mg/ml).
 
Shipping:Ambient
 
Short Term Storage:-20°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for 1 year as supplied.  Stock solutions can be stored at -20°C for up to 3 months.
 
BML-EI385
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BML-EI385

Product Literature References

The anti-angiogenic VEGF isoform VEGF165b transiently increases hydraulic conductivity , probably through VEGF receptor 1 in vivo.: C.A. Glass, et al.; J. Physiol. 572, 243 (2006), Abstract;
Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF: A. Endo, et al.; J. Recept. Signal Transduct. Res. 23, 239 (2003), Abstract;
ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity: C.E. Whittles, et al.; Microcirculation 9, 513 (2002), Abstract;

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