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ZM-447439

Aurora kinase inhibitor
 
BML-EI373-0001 1 mg 72.00 USD
 
BML-EI373-0010 10 mg 312.00 USD
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ZM-447439 is a potent and selective inhibitor of Aurora B kinase (IC50=50nM), Aurora A and C are inhibited at higher concentrations (IC50=1000nM and 250nM respectively). Other kinases such as Cdk1 and PLK1 are not inhibited (up to 10mM). Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail.

Product Specification

Formula:C29H31N5O4
 
MW:513.6
 
CAS:331771-20-1
 
Purity:≥98% (TLC)
 
Solubility:Soluble in DMSO (25 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts: E. Walsby, et al.; Haematologica 93, 662 (2008), Abstract;
ZM 447439 inhibition of aurora kinase induces Hep2 cancer cell apoptosis in three-dimensional culture: Z.J. Long, et al.; Cell Cycle 7, 1473 (2008), Abstract;
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores: C. Ditchfield, et al.; J. Cell Biol. 161, 267 (2003), Abstract;

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