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SD-169

p38 inhibitor
 
BML-EI371-0010 10 mg 63.00 USD
 
BML-EI371-0050 50 mg 163.00 USD
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A selective inhibitor of p38α (IC50 = 3.2nM) and p38β (IC50 = 3.2nM), but not p38γ (IC50 > 50μM), ERK2, JNK1 or MAPKAP2. Lowers blood glucose and improves glucose homeostasis in nonobese diabetic mice. Enhances axonal regeneration in animals with nerve transection.

Product Specification

Alternative Name:1H-Indole-5-carboxamide
 
Formula:C9H8N2O
 
MW:160.2
 
CAS:1670-87-7
 
Purity:≥96.5% (HPLC)
 
Identity:Determined by IR.
 
Appearance:White to off-white crystalline powder.
 
Solubility:Soluble in water (1.5mg/ml); DMSO (15mg/ml) or Ethanol (15mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes: S. Medicheria, et al.; J. Pharmacol. Exp. Ther. 318, 99 (2006), Abstract; Full Text
Inhibition of p38 MAP kinase activity enhances axonal regeneration: R. R. Myers, et al.; Exp. Neurol. 184, 606 (2003), Abstract;

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