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Stattic

STAT inhibitor
 
BML-EI368-0010 10 mg 58.00 USD
 
BML-EI368-0050 50 mg 215.00 USD
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Small molecule STAT3-specific inhibitor which blocks activation, dimerization and nuclear translocation via binding to the STAT3 SH2 domain. It is a very useful tool for exploring STAT3-mediated signaling pathways. It blocks LPS-mediated STAT3 tyrosine phosphorylation which leads to inhibition of LPS-mediated IL-1β and IL-6 production. In primary cultures of rat neural stem cells it blocks IL-15-induced differentiation.

Product Specification

Alternative Name:6-Nitro[b]thiophene-1,1-dioxide
 
Formula:C8H5NO4S
 
MW:211.2
 
CAS:19983-44-9
 
Purity:≥98% (TLC)
 
Appearance:Pale yellow solid.
 
Solubility:Soluble in DMSO (>25 mg/ml), 100% ethanol (10 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Osmotic regulation of NFAT5 expression in RPE cells: The involvement of purinergic receptor signaling: M. Hollborn, et al.; Mol. Vis. 23, 116 (2017), Abstract; Full Text
Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA: A. Brosig, et al.; Mol. Vis. 21, 1000 (2015), Application(s): Cell Culture, Abstract; Full Text
Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5: M. Hollborn, et al.; Mol. Vis. 21, 360 (2015), Application(s): Cell Culture, Abstract; Full Text
Effects of interleukin-15 on neuronal differentiation of neural stem cells: Y.S. Huang, et al.; Brain Res. 1304, 38 (2009), Abstract;
STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria: L. Samavati, et al.; Mol. Immunol. 46, 1867 (2009), Abstract;
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization: J. Schust, et al.; Chem. Biol. 13, 1235 (2006), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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