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AAL-993

VEGFR inhibitor
 
BML-EI367-0005 5 mg 152.00 USD
 
BML-EI367-0025 25 mg 609.00 USD
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Highly potent inhibitor of VEGFR-1 (IC50=130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and CSF-1R (380nM).

Product Specification

Alternative Name:2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide
 
Formula:C20H16F3N3O
 
MW:371.4
 
CAS:269390-77-4
 
Purity:≥98% (HPLC)
 
Appearance:Pale yellow solid.
 
Solubility:Soluble in DMSO (>25 mg/ml) or ethanol (15 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
 
BML-EI367 structure
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BML-EI367 structure

Product Literature References

Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis: P. W. Manley, et al.; Biochim. Biophys. Acta 1697, 17 (2004), Abstract;
Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors: P. W. Manley, et al.; J. Med. Chem. 45, 5687 (2002), Abstract;

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