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SL-327

MEK inhibitor
 
BML-EI365-0001 1 mg 61.00 USD
 
BML-EI365-0010 10 mg 190.00 USD
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A selective inhibitor of MEK1 and MEK2 (IC50= 0.18 and 0.22 µM respectively). Displays neuroprotective effects against ischemic brain injury.

Product Specification

Alternative Name:[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
 
Formula:C16H12F3N3S
 
MW:335.4
 
CAS:305350-87-2
 
Purity:≥99% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO to 100 mM or in ethanol to 100 mM.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
BML-EI365 structure
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BML-EI365 structure

Product Literature References

Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells: A. Sato, et al.; Stem Cell Res. 12, 119 (2014), Application(s): WB of human glioma-initiating cells, Abstract;
Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis: X. Wang, et al.; J. Pharmacol. Exp. Ther. 304, 172 (2003), Abstract; Full Text
Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy: P. A. Scherle, et al.; J. Biol. Chem. 275, 37086 (2000), Abstract; Full Text

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