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GW-441756

TrkA inhibitor
 
BML-EI364-0010 10 mg 152.00 USD
 
BML-EI364-0050 50 mg 609.00 USD
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Potent and selective inhibitor of NGFR kinase (TrkA, IC50=2 nM). Blocks TrkA-mediated γH2AX production and apoptosis in TrkA-overexpressing cells.

Product Specification

Formula:C17H13N3O
 
MW:275.3
 
CAS:504433-23-3
 
Purity:≥98% (TLC); mixture of E and Z isomers
 
Appearance:Orange solid.
 
Solubility:Soluble in DMSO (>25 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
 
BML-EI364 structure
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BML-EI364 structure

Product Literature References

Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells: E.J. Jung, et al.; Exp. Mol. Med. 40, 276 (2008), Abstract; Full Text

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