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NF-κB inhibitor
 
BML-EI352-0001 1 mg 124.00 USD
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Inhibitor of NF-κB which displays potent inhibitory effects on both NF-κB transcriptional activation (IC50=11nM) and TNF-α production (IC50= 7nM). A useful tool to explore the role of NF-κB in cellular signaling pathways.

Product Specification

Formula:C22H20N4O
 
MW:356.4
 
CAS:545380-34-5
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (20 mg/ml); DMF (30mg/ml); 100% ethanol (10 mg/ml); not soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells: S. Choi, et al.; J. Biol. Chem. 281, 12722 (2006), Abstract;
A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives: M. Tobe, et al.; Bioorg. Med. Chem. 11, 3869 (2003), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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