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HET-0016

Cytochrome P450 inhibitor
 
BML-EI350-0005 5 mg 90.00 USD
 
BML-EI350-0025 25 mg 349.00 USD
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HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A. It inhibits cerebrovascular constriction induced by Ca2+ or arachidonate and inhibits angiogenesis and endothelial cell sprouting in various models.

Product Specification

Alternative Name:N-Hydroxy-N'-(4-butyl-2-methylphenyl)formamidine
 
Formula:C12H18N2O
 
MW:206.3
 
CAS:339068-25-6
 
Purity:≥98% (TLC)
 
Appearance:Light pink solid.
 
Solubility:Soluble in DMSO (6 mg/ml)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20ºC for up to 1 year. Store solutions at -20ºC for up to 3 months
 
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Product Literature References

Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia: S. M. Poloyac, et al.; J. Cereb. Blood Flow Metab. 26, 1551 (2006), Abstract;
Calcium transients in astrocyte endfeet cause cerebrovascular constrictions: S. J. Mulligan & B. A. MacVicar; Nature 431, 195 (2004), Abstract;
Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels: Jiang, et al.; Circ. Res. 94, 167 (2004), Abstract; Full Text
CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis: S. L. Amaral, et al.; Am. J. Physiol. Heart Circ. Physiol. 284, H1528 (2003), Abstract; Full Text
HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme: N. Miyata, et al.; Br. J. Pharmacol. 133, 325 (2001), Abstract;

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