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URB-754

Monoacylglycerol lipase inhibitor
 
BML-EI349-0050 50 mg Inquire for pricing
 
BML-EI349-0010 10 mg Inquire for pricing
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Replaces Prod. #: ALX-550-410

Originally described as a potent and selective inhibitor of MAG lipase which selectively raises levels of 2-arachidonoylglycerol (2AG). Subsequent studies have shown that that URB-754 does not inhibit recombinant MAG Lipase and that the original activity was due to a contaminant, bis(methylthio)mercurane, in another commercial source.

Product Specification

Formula:C16H14N2O2
 
MW:266.3
 
CAS:86672-58-4
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
MeltingPoint:238-240°C
 
Solubility:Soluble in DMSO (15mg/ml)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:Protect from light.
 
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Product Literature References

Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro: S. Vandervoorde, et al.; Br. J. Pharmacol. 150, 186 (2007), Abstract;
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus: J.K. Makara, et al.; Natl. Neurosci. 10, 134 (2007), Full Text
URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain: S.M. Saario, et al.; Chem. Biol. 13, 811 (2006), Abstract;
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus: J.K. Makara, et al.; Nat. Neurosci. 8, 1139 (2005), Abstract;

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