Replaces Prod. #: ALX-270-371
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.
Product Details
| Alternative Name: | DMOG, N-(Methoxyoxoacetyl)-glycine methyl ester |
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| Formula: | C6H9NO5 |
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| MW: | 175.1 |
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| CAS: | 89464-63-1 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml), 100% ethanol (>25mg/ml) or dimethyl formamide; soluble also in PBS, pH7.2 (10mg/ml). |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Expression of N-WASP is regulated by HiF1α through the hypoxia response element in the N-WASP promoter : A. Salvi & T. Thanabalu; Biochem. Biophys. Rep.
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Full Text
Loss of HIF-1α in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model: N. Henke, et al.; Oncotarget.
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Application(s): Cell culture and incubation, bone-marrow-derived and peritoneal macrophages,
Abstract;
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Mutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma: A. Ordóñez-Navadijo, et al.; Oncogene
35, 587 (2016),
Application(s): Inhibition Assay,
Abstract;
The Chorioallantoic Membrane of the Chick Embryo to Assess Tumor Formation and Metastasis: A. Hermann, et al.; Methods Mol. Biol.
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Abstract;
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung: T.M. Asikainen, et al.; Proc. Natl. Acad. Sci. USA
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Abstract;
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Abstract;
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Abstract;
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Abstract;
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Abstract;
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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation: P. Jaakkola, et al.; Science
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