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Dimethyloxaloylglycine

Prolyl-4-hydroxylase inhibitor
 
BML-EI347-0010 10 mg 75.00 USD
 
BML-EI347-0050 50 mg 309.00 USD
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Replaces Prod. #: ALX-270-371

DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.

Product Specification

Alternative Name:DMOG, N-(Methoxyoxoacetyl)-glycine methyl ester
 
Formula:C6H9NO5
 
MW:175.1
 
CAS:89464-63-1
 
Purity:≥99% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (>25mg/ml), 100% ethanol (>25mg/ml) or dimethyl formamide; soluble also in PBS, pH7.2 (10mg/ml).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied.  Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Expression of N-WASP is regulated by HiF1α through the hypoxia response element in the N-WASP promoter : A. Salvi, et al.; Biochem. Biophys. Rep. (2016),
Loss of HIF-1α in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model: N. Henke, et al.; Oncotarget. 7, 25915 (2016), Application(s): Cell culture and incubation, bone-marrow-derived and peritoneal macrophages, Abstract; Full Text
Mutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma: A. Ordóñez-Navadijo, et al.; Oncogene 35, 587 (2016), Application(s): Inhibition Assay, Abstract;
The Chorioallantoic Membrane of the Chick Embryo to Assess Tumor Formation and Metastasis: A. Hermann, et al.; Methods Mol. Biol. 1464, 97 (2016), Abstract;
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung: T.M. Asikainen, et al.; Proc. Natl. Acad. Sci. USA 102, 10212 (2005), Abstract;
HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation: R. Ockaili, et al.; Am. J. Physiol. Heart Circ. Physiol. 286, H542 (2005), Abstract;
Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells: T.M. Asikainen, et al.; Free Radic. Biol. Med. 38, 1002 (2005), Abstract;
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases: P. Koivunen, et al.; J. Biol. Chem. 279, 9899 (2004), Abstract;
Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice: M. Milkiewicz, et al.; J. Physiol. 560, 21 (2004), Abstract;
A conserved family of prolyl-4-hydroxylases that modify HIF: R.K. Bruick, et al.; Science 294, 1337 (2001), Abstract;
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing: M. Ivan, et al; Science 292, 464 (2001), Abstract;
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation: P. Jaakkola, et al.; Science 292, 468 (2001), Abstract;

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