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BML-259

CDK inhibitor
 
BML-EI344-0005 5 mg 78.00 USD
 
BML-EI344-0025 25 mg 272.00 USD
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Replaces Prod. #: ALX-270-487

Potent inhibitor of Cdk5/p25 (IC50=64 nM). Also inhibits Cdk2/cyclin E (IC50=98nM).

Product Specification

Alternative Name:N-(5-Isopropylthiazol-2-yl)phenylacetamide
 
Formula:C14H16N2OS
 
MW:260.4
 
CAS:267654-00-2
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
MeltingPoint:150-152°C
 
Solubility:Soluble in DMSO (30mg/ml), dimethyl formamide (30mg/ml) or 100% ethanol (0.25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease: C.J. Helal, et al.; Bioorg. Med. Chem. Lett. 14, 5521 (2004), Abstract;

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