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United States 

SC-514

IKK inhibitor
 
BML-EI343-0010 10 mg 88.00 USD
 
BML-EI343-0050 50 mg 334.00 USD
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Selective, reversible and ATP-competitive inhibitor of IKK2 (IC50=11.2µM). Does not inhibit other IKK isoforms or other serine/threonine or tyrosine kinases. Inhibits transcription of NF-κB dependent genes in IL-1β-induced rheumatoid arthritis-derived synovial fibroblasts in a dose-dependent fashion.

Product Specification

Formula:C9H8N2OS2
 
MW:224.3
 
CAS:354812-17-2
 
Purity:≥98% (TLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (>25mg/ml)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling: If resuspended in solution, store at -20°C.
 
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Product Literature References

Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes: A. Shah, et al.; J. Neuroinflammation 9, 52 (2012), Abstract;
A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts: N. Kishore, et al.; J. Biol. Chem. 278, 32861 (2003), Abstract;

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