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Ro 48-8071

Oxido-squalene cyclase inhibitor
 
BML-EI342-0010 10 mg 78.00 USD
 
BML-EI342-0050 50 mg 317.00 USD
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Inhibits cholesterol biosynthesis at the level of 2,3-oxidosqualene cyclase (OSC). Blocks OSC and cholesterol synthesis in HepG2 cells in the nanomolar range. A novel lipid lowering agent.

Product Specification

MW:564.4
 
CAS:189197-69-1
 
Purity:≥95% (HPLC)
 
Appearance:Pale yellow solid.
 
Solubility:Soluble in water (25 mg/ml)
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year.  Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes: S. D. Shenoy, et al.; Mol. Pharmacol. 65, 1302 (2004), Abstract;
Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin: O. H. Morand, et al.; J. Lipid. Res. 38, 373 (1997), Abstract;

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