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APHS

COX inhibitor
 
BML-EI339-0010 10 mg Inquire for pricing
 
BML-EI339-0050 50 mg 310.00 USD
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A selective COX-2 inhibitor (IC50=0.8 µM) that covalently modifies the enzyme by acetylation of Ser530. APHS is an inhibitor of HIV-1 replication.

Product Specification

Alternative Name:2-Acetoxyphenylhept-2-ynylsulfide
 
Formula:C15H18O2S
 
MW:262.4
 
CAS:209125-28-0
 
Purity:≥98% (TLC)
 
Appearance:Oil.
 
Solubility:Soluble in DMSO (5mg/ml) or 100% ethanol (8mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20ºC for up to 1 year. Store solutions at -20ºC for up to 3 months.
 
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Product Literature References

Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication: C. F. Pereire, et al.; Antiviral Res. 58, 253 (2003), Abstract;
Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfide: P. Hochgesang, et al.; Arch. Biochem. Biophys. 409, 127 (2003), Abstract;
Aspirin-like molecules that covalently inactivate cyclooxygenase-2: A. S. Kalgurkar, et al.; Science 280, 1268 (1998), Abstract;

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