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AG-1288

Guanylyl cyclase inhibitor
 
BML-EI335-0050 50 mg 314.00 USD
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Replaces Prod. #: ALX-270-018

Tyrosine kinase inhibitor. It has been shown to block TNFα induced cytotoxicity and to block glucocorticoid-induced COX-2 activity in human amnion cells (IC50=21μM). It is also reported to inhibit guanylyl cyclase.

Product Specification

Alternative Name:α-Cyano-(3,4-dihydroxy-5-nitro)cinnamonitrile
 
Formula:C10H5N3O4
 
MW:231.2
 
CAS:116313-73-6
 
Purity:≥98% (TLC)
 
Appearance:Pale orange solid.
 
Solubility:Soluble in DMSO (35mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:Store tightly sealed in the dark. Protect from light.
 
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Product Literature References

Tyrphostins are inhibitors of guanylyl and adenylyl cyclases.: M. Jaleel et al.; Biochemistry 43, 8247 (2004), Abstract;
Tyrosine kinase inhibitors block the glucocorticoid stimulation of prostaglandin endoperoxide H synthase expression in amnion cells.: T. Zakar et al.; Can. J. Physiol. Pharmacol. 77, 138 (1999), Abstract;
Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors.: A. Novogrodsky et al.; Science 264, 1319 (1994), Abstract;

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