Fusicoccin is a diterpene glucoside with numerous effects. Fusicoccin induces H+ extrusion from plant cells by 14-3-3-dependent activation of the plasma membrane H+-ATPase. Fusicoccin induces translocation of 14-3-3 proteins from the cytosol to the membrane and causes a dramatic increase in cytosolic 14-3-3. Fusicoccin stimulates release of cytochrome c from mitochondria, cell enlargement, ion uptake, seed germination, opening the stomata, etc. Fusicoccin markedly reduces the ability of the cells to scavenge H2O2. Fusicoccin has been demonstrated to cause randomization of asymmetry of the left-right axis (heterotaxia) in Xenopus embryos.
Product Details
Alternative Name:
NSC 113500
Formula:
C36H56O12
MW:
680.8
Source:
Isolated from Fusicoccum amygdali.
CAS:
20108-30-9
Purity:
≥90% (HPLC, TLC)
Identity:
Identity determined by NMR.
Appearance:
White solid.
Solubility:
Soluble in chloroform and ethanol. Slightly soluble in ethyl acetate and ethyl ether. Sparingly soluble in acetone.
Shipping:
Ambient Temperature
Long Term Storage:
-20°C
Use/Stability:
Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:
RUO - Research Use Only
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Product Literature References
Biphasic control of cell expansion by auxin coordinates etiolated seedling development: M. Du, et al.; Sci. Adv. 8, eabj1570 (2022), Abstract; Full Text
Green Tea Catechins, (-)-Catechin Gallate, and (-)-Gallocatechin Gallate are Potent Inhibitors of ABA-Induced Stomatal Closure: K. Sato, et al.; Adv. Sci. 9, e2201403 (2022), Abstract;
Plasma membrane H+-ATPases promote TORC1 activation in plant suspension cells: C. Primo, et al.; iScience 25, 104238 (2022), Abstract; Full Text
Inhibition of catalase activity as an early response of Arabidopsis thaliana cultured cells to the phytotoxin fusicoccin: N. Beffagna & I. Lutzu; J. Exp. Bot. 58, 4183 (2007), Abstract;
Fusicoccin affects cytochrome c leakage and cytosolic 14-3-3 accumulation independent of H-ATPase activation: M. Malerba, et al.; Physiol. Plant 120, 386 (2004), Abstract;
Fusicoccin induces in plant cells a programmed cell death showing apoptotic features: M. Malerba, et al.; Protoplasma 222, 113 (2003), Abstract;
Fusicoccin signaling reveals 14-3-3 protein function as a novel step in left-right patterning during amphibian embryogenesis: T.D. Bunney, et al.; Development 130, 4847 (2003), Abstract;
Cytoskeletal inhibitors suppress the stomatal opening of Vicia faba L. induced by fusicoccin and IAA: R.F. Huang, et al.; Plant Sci. 156, 65 (2000), Abstract;
Fusicoccin binding to its plasma membrane receptor and the activation of the plasma membrane H(+)-ATPase. IV. Fusicoccin induces the association between the plasma membrane H(+)-ATPase and the fusicoccin receptor: C. Olivari, et al.; Plant Physiol. 116, 529 (1998), Abstract;
The 14-3-3 proteins associate with the plant plasma membrane H(+)-ATPase to generate a fusicoccin binding complex and a fusicoccin responsive system: L. Baunsgaard, et al.; Plant J. 13, 661 (1998), Abstract;
Fusicoccin - a key to multiple 14-3-3 locks?: A.H. De Boer; Trends Plant Sci. 2, 20 (1997),
The 14-3-3 protein interacts directly with the C-terminal region of the plant plasma membrane H(+)-ATPase: T. Jahn, et al.; Plant Cell 9, 1805 (1997), Abstract;
General Literature References
Mutational analysis of the interaction between 14-3-3 proteins and plant plasma membrane H+-ATPase: S. Visconti, et al.; J. Biol. Chem. 278, 8172 (2003), Abstract;
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex: M. Wurtele, et al.; Embo J. 22, 987 (2003), Abstract;
cDNA microarray analysis of fusicoccin-induced changes in gene expression in tomato plants: U.B. Frick & A. Schaller; Planta 216, 83 (2002), Abstract;
Metabolic enzymes as targets for 14-3-3 proteins: S.C. Huber, et al.; Plant Mol. Biol. 50, 1053 (2002), (Review), Abstract;
Phosphorylation-independent interaction between 14-3-3 protein and the plant plasma membrane H+-ATPase: J. Borch, et al.; Biochem. Soc. Trans. 30, 411 (2002), (Review), Abstract; Full Text
Plant 14-3-3 proteins assist ion channels and pumps: A.H. de Boer; Biochem. Soc. Trans. 30, 416 (2002), (Review), Abstract; Full Text
Fusicoccin binding to its plasma membrane receptor and the activation of the plasma membrane H(+)-ATPase. IV. Fusicoccin induces the association between the plasma membrane H(+)-ATPase and the fusicoccin receptor: C. Olivari, et al.; Plant Physiol. 116, 529 (1998), Abstract;
Fusicoccin - a key to multiple 14-3-3 locks?: A.H. De Boer; Trends Plant Sci. 2, 20 (1997), (Review),
Fusicoccin receptors: perception and transduction of the fusicoccin signal: P. Aducci et al.; J. Exp. Bot. 46, 1463 (1995), (Review),
Fusicoccin: a tool in plant physiology: E. Marre; Ann. Rev. Plant Physiol. 30, 273 (1979), (Review),
