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URB-597

FAAH inhibitor
 
BML-EI327-0025 25 mg 167.00 USD
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Replaces Prod. #: ALX-550-382

URB-597 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is involved in the hydrolysis of endogenous cannabinoids such as anandamide. Inhibition of FAAH may serve to enhance the analgesic effects of endogenous cannabinoids. URB-597 has been shown to inhibit FAAH in rat cortical neuron membranes and in intact neurons with IC50 values of 4.6nM and 0.5nM, respectively. The compound has also been shown to have anxiolytic effects in rats (ID50=0.15mg/kg). Because URB-597 acts on FAAH and does not interfere with the binding of anandamide to the CB1 and CB2 receptors, it is a novel tool for drug development.

Product Specification

Alternative Name:Cyclohexylcarbamic acid 3'-carbamoyl-biphenyl-3-yl ester
 
Formula:C20H22N2O3
 
MW:338.4
 
CAS:546141-08-6
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
MeltingPoint:155-157°C
 
Solubility:Soluble in 100% ethanol (1mg/ml), dimethyl formamide (10mg/ml) or DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutons at -20°C for up to 3 months.
 
Handling:Protect from light.
 
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Product Literature References

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors: X. Viñals, et al.; PLoS Biol. 13, e1002194 (2015), Application(s): Injection into mice, Abstract; Full Text
Modulation of anxiety through blockade of anandamide hydrolysis: S. Kathuria et al.; Nat. Med. 9, 76 (2003), Abstract;
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides: B.F. Cravatt et al.; Nature 384, 83 (1996), Abstract;

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