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Mu-Phe-hPhe-FMK

Cathepsin inhibitor
 
BML-EI323-0001 1 mg 201.00 USD
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Irreversible, non-toxic, cell-permeable inhibitor of cysteine proteases calpain, cathepsins B and L, and Trypanosome trypanopain. Can be used in vitro (typically 20 µM) or in vivo. Inhibits tumor formation and growth.

Product Specification

Alternative Name:N-Morpholineurea-phenylalanyl-homophenylalanylfluoromethyl ketone
 
Sequence:Mu-Phe-hPhe-FMK
 
Formula:C25H30FN3O4
 
MW:455.5
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (>25 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Use/Stability:Store, as supplied, at 4°C for up to 1 year. Store DMSO concentrates at -20°C for up to 1 year. Do not store dilute solutions.
 
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Product Literature References

Calpain inhibitor 2 prevents axonal degeneration of opossum optic nerve fibers: L. A. Couto, et al.; J. Neurosci. Res. 77, 410 (2004), Abstract;
Glycosylphosphatidylinositol-dependent protein trafficking in bloodstream stage Trypanosoma brucei: V. P. Triggs & J. D. Bangs; Eukaryot. Cell. 2, 76 (2003), Abstract; Full Text
Heterogeneous suppression of experimentally induced colon cancer metastasis in rat liver lobes by inhibition of extracellular cathepsin B: C. J. F. Van Noorden, et al.; Clin. Exp. Metastasis 16, 159 (1998), Abstract;
Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo: M.M. Wasilewski, et al.; Mol. Biochem. Parasitol. 81, 179 (1996), Abstract;
The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design: J.H. McKerrow, et al.; Parasitol. Today 11, 279 (1995), Abstract;
Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis: R. E. Esser, et al.; Arthritis Rheum. 37, 236 (1994), Abstract;
Selective inhibition of cysteine proteinases by Z-Phe-AlaCH2F suppresses digestion of collagen by fibroblasts and osteoclasts: C. J. F. Van Noorden & V. Everts; Biochem. Biophys. Res. Commun. 178, 178 (1991), Abstract;

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