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Exo1

ADP-ribosylation factor inhibitor
 
BML-EI322-0010 10 mg 72.00 USD
 
BML-EI322-0050 50 mg 276.00 USD
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Exo1 inhibits traffic emanating from the endoplasmic reticulum by inducing rapid collapse of the Golgi to the endoplasmic reticulum1. Like Brefeldin A, Exo1 induces the rapid release of ARF1 from Golgi membranes, but evidence suggests that Exo1 acts by a different mechanism. Exo1 does not induce the ADP-ribosylation of CtBP/Bars50, and does not interfere with the activity of guanine nucleotide exchange factors specific for Golgi-based ARFs, allowing Exo1 to be used as a tool for differentiating the fatty acid exchange activity of Bars50 from ARF1 activity.

Product Specification

Alternative Name:2-[(4-Fluorobenzoyl)amino]benzoic acid methyl ester
 
Formula:C15H12FNO3
 
MW:273.3
 
CAS:461681-88-9
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
MeltingPoint:132-134°C
 
Solubility:Soluble in DMSO (10 mg/ml warm), DMF (20 mg/ml), or ethanol (5 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store solutions at -20ºC for up to 3 months.
 
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Product Literature References

Exo1: a new chemical inhibitor of the exocytic pathway: Y. Feng, et al.; Proc. Natl. Acad. Sci. USA 100, 6469 (2003), Abstract; Full Text

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