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Terbinafine HCl

Squalene epoxidase inhibitor
BML-EI318-0100 100 mg 77.00 USD
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Inhibits ergosterol biosynthesis at the level of squalene epoxidase. Potent non-competitive inhibitor of squalene epoxidase from Candida (Ki=30 nM), inhibiting mammalian enzymes at higher concentrations (4-77 µM). It inhibits HUVEC proliferation and angiogenesis and displays interesting anti-inflammatory and free radical scavenging activities. Clinically useful antifungal agent.

Product Specification

Alternative Name:trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine . hydrochloride
Formula:C21H25N . HCl
Purity:≥98% (UHPLC)
Appearance:White to off-white solid.
Solubility:Soluble in ethanol (45 mg/ml), DMSO (30 mg/ml) or water (3 mg/ml).
Long Term Storage:Ambient
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Product Literature References

Inhibition of human vascular endothelial cells proliferation by terbinafine: P. Y. Ho, et al.; Int. J. Cancer 111, 51 (2004), Abstract;
Inhibitory effect of terbinafine on reactive oxygen species (ROS) generation by Candida albicans: C. S. Sander, et al.; Mycoses 45, 152 (2002), Abstract;
Anti-inflammatory activity of antifungal preparations: T. Rosen, et al.; Int. J. Dermatol. 36, 788 (1997), Abstract;
Differential inhibition of fungal amd mammalian squalene epoxidases by the benzylamine SDZ SBA 586 in comparison with the allylamine terbinafine: B. Favre, et al.; Arch. Biochem. Biophys. 340, 265 (1997), Abstract;
Terbinafine: mode of action and properties of the squalene epoxidase inhibition: N. S. Ryder, et al.; Br. J. Dermatol. 126, 39 (1992), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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