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TMP-153

ACAT inhibitor
 
BML-EI317-0020 20 mg 68.00 USD
 
BML-EI317-0100 100 mg 279.00 USD
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TMP-153 is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), IC50=5-10 nM. It inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals.

Product Specification

Formula:C24H18ClF2N3O
 
MW:437.9
 
CAS:128831-46-9
 
Purity:≥98%
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (>25mg/ml) or ethanol (10mg/ml with warming).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome: N.D. Vaziri, et al.; Circulation 110, 419 (2004), Abstract; Full Text
TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters: Y. Sugiyama, et al.; Atherosclerosis 113, 71 (1995), Abstract;
TMP-153, a novel ACAT inhibitor, lowers plasma cholesterol through its hepatic action in golden hamsters: Y. Sugiyama, et al.; Atherosclerosis 118, 145 (1995), Abstract;

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