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Blebbistatin(+/-)

Inhibitor of non-muscle myosin II
 
BML-EI315-0005 5 mg 120.00 USD
 
BML-EI315-0025 25 mg 460.00 USD
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Blebbistatin (so named because of its ability to block cell blebbing) is a selective and high-affinity (IC50 approx. 4 µM) inhibitor of non-muscle myosin II. During cell division blebbistatin inhibits contraction of the cleavage furrow without disrupting mitosis. It inhibits pancreatic adenocarcinoma cellular invasiveness and PDGF-stimulated fibroblast-collagen matrix contraction.

Product Specification

Formula:C18H16N2O2
 
MW:292.3
 
CAS:674289-55-5
 
Purity:≥97%
 
Appearance:Bright yellow solid.
 
Solubility:Soluble in DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury: T. Grevesse, et al.; Sci. Rep. 5, 9475 (2015), Application(s): Cell Culture, Abstract; Full Text
Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment: J. Shi, et al.; Cell Death Dis. 4, e483 (2013), Abstract; Full Text
The nucleus of endothelial cell as a sensor of blood flow direction: E. Tkachenko, et al.; Biol. Open 2, 1007 (2013), Abstract; Full Text
Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor: M.S. Duxbury, et al.; Biochem. Biophys. Res. Commun. 313, 992 (2004), Abstract;
Mechanism of blebbistatin inhibition of myosin II: M. Kovacs, et al.; J. Biol. Chem. 279, 35557 (2004), Abstract; Full Text
Different molecular motors mediate platelet-derived growth factor and lysophosphatidic acid-stimulated floating collagen matrix contraction: M. Abe, et al.; J. Biol. Chem. 278, 47707 (2003), Abstract; Full Text
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor: A.F. Straight, et al.; Science 299, 1743 (2003), Abstract;

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