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Blebbistatin(+/-)

Inhibitor of non-muscle myosin II
 
BML-EI315-0005 5 mg 126.00 USD
 
BML-EI315-0025 25 mg 483.00 USD
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Blebbistatin (so named because of its ability to block cell blebbing) is a selective and high-affinity (IC50 approx. 4 µM) inhibitor of non-muscle myosin II. During cell division blebbistatin inhibits contraction of the cleavage furrow without disrupting mitosis. It inhibits pancreatic adenocarcinoma cellular invasiveness and PDGF-stimulated fibroblast-collagen matrix contraction.

Product Specification

Formula:C18H16N2O2
 
MW:292.3
 
CAS:674289-55-5
 
Purity:≥97%
 
Identity:Determined by NMR.
 
Appearance:Bright yellow solid.
 
Solubility:Soluble in DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy: C.W. Hsieh, et al.; Nat. Commun. 10, 969 (2019), Application(s): added during cell culture to screen for functional and structrual changes in mitophagy in HeLa cells expressing EBFP-2-Parkin, EGFP-dMito and KillerRed-dMito, Abstract; Full Text
Control of endothelial cell polarity and sprouting angiogenesis by non-centrosomal microtubules.: M. Martin, et al.; Elife 7, e33864 (2018), Abstract; Full Text
Tropomyosin isoform Tpm2.1 regulates collective and amoeboid cell migration and cell aggregation in breast epithelial cells: H. Shin, et al.; Oncotarget 56, 95192 (2017), Abstract; Full Text
Myosin VI regulates gene pairing and transcriptional pause release in T cells.: C.E. Zorca, et al.; PNAS 13, E1587 (2015), Abstract; Full Text
Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury: T. Grevesse, et al.; Sci. Rep. 5, 9475 (2015), Application(s): Cell Culture, Abstract; Full Text
Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment: J. Shi, et al.; Cell Death Dis. 4, e483 (2013), Abstract; Full Text
The nucleus of endothelial cell as a sensor of blood flow direction: E. Tkachenko, et al.; Biol. Open 2, 1007 (2013), Abstract; Full Text
Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor: M.S. Duxbury, et al.; Biochem. Biophys. Res. Commun. 313, 992 (2004), Abstract;
Mechanism of blebbistatin inhibition of myosin II: M. Kovacs, et al.; J. Biol. Chem. 279, 35557 (2004), Abstract; Full Text
Different molecular motors mediate platelet-derived growth factor and lysophosphatidic acid-stimulated floating collagen matrix contraction: M. Abe, et al.; J. Biol. Chem. 278, 47707 (2003), Abstract; Full Text
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor: A.F. Straight, et al.; Science 299, 1743 (2003), Abstract;

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