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Ikarugamycin

Inhibits endocytosis; inhibits LDL uptake
 
BML-EI313-0500 500 µg 212.00 USD
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Ikarugamycin inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages. It blocks PMA and Nef-mediated cell surface CD4 down-regulation. Ikarugamycin is emerging as a general inhibitor of clathrin-coated pit-mediated endocytosis and appears to be a useful agent for studying the process of endocytosis.

Product Specification

Formula:C29H38N2O4
 
MW:478.6
 
CAS:36531-78-9
 
Purity:≥95% (HPLC, TLC)
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in DMFA, DMSO or THF.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
BML-EI313
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BML-EI313

Product Literature References

Distinct endocytic pathways identified in tobacco pollen tubes using charged nanogold: A. Moscatelli, et al.; J. Cell. Sci. 120, 3804 (2007), Abstract; Full Text
Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycin: T. Luo, et al.; J. Virol. 75, 2488 (2001), Abstract; Full Text
Inhibition of the uptake of oxidized low-density lipoprotein in macrophage J774 by the antibiotic ikarugamycin: K. Hasumi, et al.; Eur. J. Biochem. 205, 841 (1992), Abstract; Full Text

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