Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

SB-216763

GSK inhibitor
 
BML-EI312-0001 1 mg 68.00 USD
 
BML-EI312-0005 5 mg 209.00 USD
Do you need bulk/larger quantities?
 
Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model.

Product Specification

Formula:C19H12Cl2N2O2
 
MW:371.2
 
CAS:280744-09-4
 
Purity:≥98% (TLC)
 
Appearance:Orange solid
 
Solubility:Soluble in DMSO (>25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
bml-ei312
Please mouse over
bml-ei312

Product Literature References

GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity: A.A. Culbert, et al.; FEBS Lett. 507, 288 (2001), Abstract;
Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression: P.A. Lochhead, et al.; Diabetes 50, 937 (2001), Abstract;
Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death: D.A.E. Cross, et al.; J. Neurochem. 77, 94 (2001), Abstract;
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription: M.P. Coghlan, et al.; Chem. Biol. 7, 793 (2000), Abstract;

Related Products

GSK-3β (human), (recombinant) (GST-tag) 

Produced in insect cells. Full length human glycogen synthase kinase-3ß is fused at the N-terminus to a GST-tag. Produced in a baculovirus expression system. | Print as PDF
 
BML-SE355-0005 5 µg 265.00 USD
Do you need bulk/larger quantities?
 

Related Literature

Brochures
Integrated solutions for screening Wnt regulators
Integrated solutions for screening Wnt regulators
Download as PDF

Brochures
Stem Cells
Stem Cells
Download as PDF

Catalogs
Diabetes Catalog
Diabetes Catalog
Download as PDF

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,