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SB-415286

GSK inhibitor
 
BML-EI311-0001 1 mg 66.00 USD
 
BML-EI311-0005 5 mg 209.00 USD
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Potent and selective inhibitor of GSK-3β (IC50=78nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke.

Product Specification

Formula:C16H10N3O5Cl
 
MW:359.7
 
CAS:264218-23-7
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Yellow Solid.
 
Solubility:Soluble in DMSO, ethanol or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity: A.A. Culbert, et al.; FEBS Lett. 507, 288 (2001), Abstract;
Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death: D.A.E. Cross, et al.; J. Neurochem. 77, 94 (2001), Abstract;
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription: M.P. Coghlan, et al.; Chem. Biol. 7, 793 (2000), Abstract;

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