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GW5074

Raf inhibitor
 
BML-EI307-0005 5 mg 112.00 USD
 
BML-EI307-0025 25 mg 441.00 USD
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Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

Product Specification

Alternative Name:5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone
 
Formula:C15H8Br2INO2
 
MW:520.9
 
CAS:220904-83-6
 
Purity:≥98% (TLC)
 
Appearance:Yellow to orange solid.
 
Solubility:Soluble in DMSO (>25 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for at least 6 months when stored at -20°C.
 
Handling:Protect from light. Keep under inert gas.
 
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Product Literature References

Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway: J. Huang, et al.; J. Pharmacol. Sci. 102, 305 (2006), Abstract;
Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways: M.S. Chang, et al.; Cell Signal. 17, 299 (2005), Abstract;
Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells: B.C. Chen, et al.; J. Immunol. 173, 5219 (2004), Abstract;
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism: P.C. Chin, et al.; J. Neurochem. 90, 595 (2004), Abstract;
The discovery of potent cRaf1 kinase inhibitors: K. Lackey, et al.; Bioorg. Med. Chem. Lett. 10, 223 (2000), Abstract;

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