Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

SP600125

Jnk inhibitor
 
BML-EI305-0010 10 mg 68.00 USD
 
BML-EI305-0050 50 mg 282.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-270-339

Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.

Product Specification

Alternative Name:Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone
 
Formula:C14H8N2O
 
MW:220.2
 
CAS:129-56-6
 
RTECS:CB4585000
 
Purity:≥98% (TLC)
 
Appearance:Yellow to brown solid.
 
Solubility:Soluble in DMSO or methanol.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light. Keep under inert gas.
 
Technical Info/Product Notes:Note: Product is not sterile.
Replacement for ADI-HPK-111.
 
bml-ei305
Please mouse over
bml-ei305

Product Literature References

Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis: K. Hu, et al.; Cell Death Dis. 8, e2637 (2017), Abstract; Full Text
Myricetin suppresses invasion and promotes cell death in human placental choriocarcinoma cells through induction of oxidative stress: C. Yang, et al.; Cancer Lett. 399, 10 (2017), Abstract;
Calcitonin gene-related peptide is a key factor in the homing of transplanted human MSCs to sites of spinal cord injury: Y. Zhang, et al.; Sci. Rep. 6, 27724 (2016), Application(s): Migration assay in Boyden chamber, Abstract; Full Text
Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress: Z.C. Lin, et al.; Int. J. Nanomedicine 11, 2907 (2016), Application(s): Cell treatment to see effect on PM-induced phosphorylation, Abstract; Full Text
Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells: Y. Hosokawa, et al.; Inflammation (2016), Abstract;
Hypotonic Stress-Induced Down-Regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-Dependent Endocytosis in Renal Tubular Epithelial Cells: N. Fujii, et al.; J. Biol. Chem. 291, 24787 (2016), Application(s):, Abstract; Full Text
NORE1A induction by membrane-bound CD40L (mCD40L) contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism: T. Elmetwali, et al.; Cell Death Dis. 7, e2146 (2016), Application(s): Cell culture, Abstract;
Tunicamycin-induced Endoplasmic Reticulum Stress Upregulates the Expression of Pentraxin 3 in Human Retinal Pigment Epithelial Cells: N. Hwang, et al.; Korean J. Ophthalmol. 30, 468 (2016), Abstract; Full Text
Amphiregulin may be a new biomarker of classically activated macrophages: C. Meng, et al.; Biochem. Biophys. Res. Commun. 466, 393 (2015), Application(s): Cell Culture, Abstract;
Andrographolide decreased VEGFD expression in hepatoma cancer cells by inducing ubiquitin/proteasome-mediated cFos protein degradation: L. Ji, et al.; Biochim. Biophys. Acta. 1850, 750 (2015), Application(s): Cell Culture, Abstract;
CArG-driven GADD45α activated by resveratrol inhibits lung cancer cells: Q. Shi, et al.; Genes Cancer 6, 220 (2015), Application(s): Cell Culture, Abstract; Full Text
Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells: W. Qi, et al.; Mol. Cell. Endocrinol. 405, 74 (2015), Application(s): Cell Culture, Abstract;
Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons: Z. Cao, et al.; Mar. Drugs 13, 903 (2015), Application(s): Cell Culture, Abstract; Full Text
Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice: W. Nemoto, et al.; Neuropharmacology 99, 221 (2015), Application(s): Injection into mice, Abstract;
Phloretin ameliorates chemokines and ICAM-1 expression via blocking of the NF-κB pathway in the TNF-α-induced HaCaT human keratinocytes: W.C. Huang, et al.; Int. Immunopharmacol. 27, 32 (2015), Application(s): Cell Culture, Western Blot, Abstract;
Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling: Y.T. Oh, et al.; Oncotarget 6, 41324 (2015), Application(s): Cell culture , Abstract; Full Text
PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-catenin pathway by phosphorylation and degradation of β-catenin: M.Y. Wu, et al.; Oncol Rep. 32, 513 (2014), Abstract; Full Text
CpG Protects Human Monocytic Cells against HIV-Vpr-Induced Apoptosis by Cellular Inhibitor of Apoptosis-2 through the Calcium-Activated JNK Pathway in a TLR9-Independent Manner: M. Saxena, et al.; J. Immunol. 187, 5865 (2011), Application(s): WB of human monocytes, Abstract; Full Text
Mechanism and Repertoire of ASC-Mediated Gene Expression: M. Hasegawa, et al.; J. Immunol. 182, 7655 (2009), Abstract;
Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs: M. Ishii, et al.; J. Immunol. 172, 2569 (2004), Abstract;
An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression: M. Shin, et al.; Biochim. Biophys. Acta 1589, 311 (2002), Abstract;
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis: Z. Han, et al.; J. Clin. Invest. 108, 73 (2001), Abstract; Full Text
Role of JNK in hypertonic activation of Cl(-)-dependent Na(+)/H(+) exchange in Xenopus oocytes: G.G. Goss, et al.; Am. J. Physiol. Cell. Physiol. 281, C1978 (2001), Abstract;
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase: B.L. Bennett, et al.; PNAS 98, 13681 (2001), Abstract; Full Text
TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells: B. Schnabl, et al.; Hepatology 34, 953 (2001), Abstract;

Related Literature

Brochures
Integrated solutions for screening Wnt regulators
Integrated solutions for screening Wnt regulators
Download as PDF

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,