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AG-1296

PDGF receptor tyrosine kinase inhibitor
 
BML-EI303-0005 5 mg 125.00 USD
 
BML-EI303-0025 25 mg 494.00 USD
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Replaces Prod. #: ALX-270-037

A potent inhibitor of PDGF receptor tyrosine kinase (IC50=1 µM). Also inhibits FGF receptor tyrosine kinase and c-kit. Induces apoptosis in a small-cell lung cancer cell line (H526).

Product Specification

Alternative Name:Tyrphostin AG 1296, 6,7-Dimethoxy-3-phenylquinoxaline
 
Formula:C16H14N2O2
 
MW:266.3
 
CAS:146535-11-7
 
Purity:≥98% (TLC)
 
Appearance:Off-white to brownish solid.
 
Solubility:Soluble in DMSO or dichloromethane.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:Store tightly sealed in the dark. Protect from light.
 
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Product Literature References

TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2): F. Strutz, et al.; Kidney Int. 59, 579 (2001), Abstract;
Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins: G.W. Krystal, et al.; Cancer Res. 57, 2203 (1997), Abstract; Full Text
Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296: M. Kovalenko, et al.; Biochemistry 36, 6260 (1997), Abstract;

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