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United States 

ZM 336372

Raf inhibitor
 
BML-EI298-0005 5 mg 141.00 USD
 
BML-EI298-0025 25 mg 583.00 USD
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Replaces Prod. #: ALX-270-336

Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50µM) with the exception of p38 (SAPK2a) (IC50=2µM) and SAPK2b (p38β) (IC50=2µM). Induces a paradoxical >100-fold activation of c-Raf in whole cells.

Product Specification

Alternative Name:N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
 
Formula:C23H23N3O3
 
MW:389.4
 
CAS:208260-29-1
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (200mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 3 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light. Keep under inert gas.
 
Technical Info/Product Notes:Note: Product is not sterile.
 
bml-ei298
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Product Literature References

Paradoxical activation of Raf by a novel Raf inhibitor: C.A. Hall-Jackson, et al.; Chem. Biol. 6, 559 (1999), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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