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PKC inhibitor
 
BML-EI296-0500 0.5 mg 141.00 USD
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PKC inhibitor. Has been shown to selectively inhibit several PKC isoenzymes (IC50 = 7nM for PKCα and PKCβ; 6nM for PKCγ; 10nM for PKCδ; 60nM for PKCζ). The compound does not effectively inhibit PKCµ (IC50=20 µM) and therefore can be used to differentiate PKCµ from other isoforms.

Product Specification

Formula:C26H26N4O3
 
MW:442.5
 
CAS:133053-19-7
 
Purity:≥95% (HPLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:Bright red solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Nitric oxide and N-acetylcysteine inhibit the activation of mitogen-activated protein kinases by angiotensin II in rat cardiac fibroblasts: D. Wang, et al.; J. Biol. Chem. 273, 33027 (1998), Abstract; Full Text
Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form: L. Stempka, et al.; J. Biol. Chem. 272, 6805 (1997), Abstract; Full Text
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes: M. Geschwendt, et al.; FEBS Lett. 392, 77 (1996), Abstract;

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