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5-Iodotubercidin

Protein kinase inhibitor
 
BML-EI293-0001 1 mg 98.00 USD
 
BML-EI293-0005 5 mg 410.00 USD
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Inhibits ERK2 (Ki = 525nM). Also inhibits adenosine kinase (Ki = 30nM), CK1 and CK2 and insulin receptor kinase (IC50 ranging from 0.4-28µM).

Product Specification

Alternative Name:4-Amino-5-iodo-7-(β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidine
 
Formula:C11H13IN04
 
MW:392.1
 
CAS:24386-93-4
 
Purity:≥98% (TLC)
 
Identity:Determined by 1H-NMR and MS
 
Appearance:Off-white solid
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (8mg/ml warm)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase: T. Fox et al.; Protein. Sci. 7, 2249 (1998), Abstract;
Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor: D. Massillon et al.; Biochem. J. 299 , 123 (1994), Abstract;

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