Replaces Prod. #: ALX-380-092
Antifungal macrocyclic lactone antibiotic with antimalarial activity. Potent inhibitor of HSP90. Binds more strongly to HSP90 (nanomolar affinity) than to Grp94. Also binds to yeast HSP90, E. coli HtpG and TRAP-1. Non-competitive inhibitor of ATP citrate lyase. Anti-angiogenic. Specifically inhibits the interaction between HIF-1α/Arnt heterodimer and the hypoxia-responsive element (HRE), reducing VEGF expression. Protein tyrosine kinase inhibitor, e.g. p60v-src (IC50=0.27nM). Inhibitor of cyclooxygenase-2 (COX-2) expression (IC50=27nM) without affecting COX-1 expression in LPS-stimulated macrophages. Induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. Suppressor of NIH 3T3 cell transformation by diverse oncogenes such as mos, ras and src in part by blocking the key signal transduction intermediates such as MAP kinase and GAP-associated p62. Inhibitor of AP-1-, NF-κB- and serum response factor (SRF)-mediated transcription (e.g. expression of iNOS). Represses the transcriptional function of the estrogen receptor. Inhibits archeal growth and DNA topoisomerase VI (a Topo IIB family topoisomerase). Blocks replication of negative-strand RNA viruses.Causes morphological reversion of ras-transformed cells and leads to selective depletion of Raf kinase. Displays anti-angiogenic activity. Binds to and inhibits Hsp 90 molecular chaperone.
Product Details
Alternative Name: | Monorden, 1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione |
|
Formula: | C18H17ClO6 |
|
MW: | 364.8 |
|
Source: | Isolated from Humicola fuscoatra. |
|
CAS: | 12772-57-5 |
|
MI: | 14: 6253 |
|
RTECS: | RR1105000 |
|
Purity: | ≥97% (HPLC) |
|
Appearance: | White to off-white or yellowish solid. May appear adhered to vial. |
|
Solubility: | Soluble in DMSO, methanol or acetone. |
|
Shipping: | Ambient Temperature |
|
Long Term Storage: | -20°C |
|
Handling: | Protect from light. |
|
Regulatory Status: | RUO - Research Use Only |
|
Please mouse over
Product Literature References
Radicicol induces intracellular accumulation of glycan-deficient clusterin variant: I. Choi, et al.; Biochem. Biophys. Res. Commun.
458, 555 (2015),
Application(s): Cell Culture,
Abstract;
Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses: J.H. Connor, et al.; Virology
362, 109 (2007),
Abstract;
Chemistry and biology of resorcylic acid lactones: N. Winssinger & S. Barluenga; Chem. Commun. (Camb.)
2007, 22 (2007), (Review),
Abstract;
Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site: M.K. Hadden, et al.; Curr. Top. Med. Chem.
6, 1173 (2006), Review,
Abstract;
Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol: K.D. Corbett & J.M. Berger; Nucleic Acids Res.
34, 4269 (2006),
Abstract;
The topoisomerase II-Hsp90 complex: a new chemotherapeutic target?: C.R. Barker, et al.; Int. J. Cancer
118, 2685 (2006),
Abstract;
Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor: K. Harashima, et al.; Int. J. Radiat. Biol.
81, 63 (2005),
Abstract;
Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol: D. Gadelle, et al.; Nucleic Acid Res.
33, 2310 (2005),
Abstract;
Development of radicicol analogues: S. Soga, et al.; Curr. Cancer Drug Targets
3, 359 (2003),
Abstract;
Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90: M.O. Lee, et al.; Mol. Cell Endocrinol.
188, 47 (2002),
Abstract;
Radicicol-sensitive peptide binding to the N-terminal portion of GRP94: S. Vogen, et al.; J. Biol. Chem.
277, 40742 (2002),
Abstract;
Full Text
Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol: E. Hur, et al.; Mol. Pharmacol.
62, 975 (2002),
Abstract;
Full Text
Radicicol suppresses transformation and restores tropomyosin-2 expression in both ras- and MEK-transformed cells without inhibiting the Raf/MEK/ERK signaling cascade: P.N. Kim, et al.; Cell Growth Differ.
12, 543 (2001),
Abstract;
Full Text
Radicicol binds and inhibits mammalian ATP citrate lyase: S.W. Ki, et al.; J. Biol. Chem.
275, 39231 (2000),
Abstract;
Full Text
Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-kappaB/Rel in lipopolysaccharide-stimulated macrophages: Y.J. Jeon, et al.; J. Pharmacol. Exp. Ther.
294, 548 (2000),
Abstract;
Full Text
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones: T.W. Schulte, et al.; Mol. Endocrinol.
13, 1435 (1999),
Abstract;
Full Text
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin: S.M. Roe, et al.; J. Med. Chem.
42, 260 (1999),
Abstract;
Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites: Y. Tanaka, et al.; J. Antibiot.
51, 153 (1998),
Abstract;
Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway: S. Soga, et al.; J. Biol. Chem.
273, 822 (1998),
Abstract;
Full Text
Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol: S.V. Sharma, et al.; Oncogene
16, 2369 (1998),
Abstract;
Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells: I. Pillay, et al.; Cell Growth Differ.
7, 1487 (1996),
Abstract;
Induction of differentiation of HL-60 cells by the anti-fungal antibiotic, radicicol: Y. Shimada, et al.; J. Antibiot.
48, 824 (1995),
Abstract;
Morphology of ras-transformed cells becomes apparently normal again with tyrosine kinase inhibitors without a decrease in the ras-GTP complex: H.J. Kwon et al.; J. Biochem.
118, 221 (1995),
Abstract;
Radicicol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis: P. Chanmugam, et al.; J. Biol. Chem.
270, 5418 (1995),
Abstract;
Full Text
Suppression of RAS and MOS transformation by radicicol: J.F. Zhao, et al.; Oncogene
11, 161 (1995),
Abstract;
Enhanced cell differentiation when RB is hypophosphorylated and down-regulated by radicicol, a SRC-kinase inhibitor: A. Yen et al.; Exp Cell Res
214, 163 (1994),
Abstract;
Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis: T. Oikawa, et al.; Eur. J. Pharmacol.
241, 221 (1993),
Abstract;
Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol: H.J. Kwon, et al.; Cancer Res.
52, 6926 (1992),
Abstract;