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Ro 31-8220

PKC inhibitor
 
BML-EI283-0001 1 mg 87.00 USD
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Replaces Prod. #: ALX-270-020

Cell-permeable PKC inhibitor. Selective for PKC (IC50=10nM) over CaM kinase II (IC50=17µM) and PKA (IC50=0.9µM). Induces apoptosis in various cell lines.

Product Specification

Alternative Name:2-[1-(3-(Amidinothio)propyl)-1H-indol-3-yl]-3-(1-methylindol-3-yl)maleimide·methanesulfonate, Bisindolylmaleimide IX . Methanesulfonate
 
Formula:C25H23N5O2S·CH4O3S
 
MW:553.7
 
CAS:138489-18-6
 
Purity:≥98%
 
Appearance:Red/orange solid.
 
Solubility:Soluble in DMSO (10mg/ml)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
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Product Literature References

Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3.: L. Shen & R.I. Glazer; Biochem. Pharmacol. 55, 1711 (1998), Abstract;
Atypical isoforms of pKc and insulin secretion from pancreatic beta-cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors.: T.E. Harris et al.; Biochem. Biophys. Res. Commun. 227, 672 (1996), Abstract;
Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors.: J. Budworth & A. Gescher; FEBS Lett. 362, 139 (1995), Abstract;
Characterisation of protein kinase C isoforms and enzymic activity from the alpha T3-1 gonadotroph-derived cell line.: M.S. Johnson et al.; FEBS Lett. 333, 67 (1993), Abstract;
Inhibition by Ro 31-8220 of acid secretory activity induced by carbachol indicates a stimulatory role for protein kinase C in the action of muscarinic agonists on isolated rat parietal cells.: J.P. McKenna & P.J. Hanson; Biochem. Pharmacol. 46, 583 (1993), Abstract;
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.: S.E. Wilkinson et al.; Biochem. J. 294, 335 (1993), Abstract;

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