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United States 

BAY 11-7085

NF-κB inhibitor
 
BML-EI279-0010 10 mg 87.00 USD
 
BML-EI279-0050 50 mg 349.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-270-220

An irreversible inhibitor of cytokine-inducible IκBα phosphorylation (IC50=10 µM). In intact HUVECs it inhibits TNFα-induced phosphorylation and degradation of IκBα without affecting constitutive phosphorylation. Inhibition of IκBα phosphorylation and degradation results in the inactivation of NF-κB and NF-κB-dependent expression of endothelial-leukocyte adhesion molecules, E-selectin, VCAM-1 and ICAM-1. BAY 11-7085 displayed potent anti-inflammatory activity in the rat carrageenan paw edema assay and adjuvant arthritis model.

Product Specification

Formula:C13H15NO2S
 
MW:249.3
 
CAS:196309-76-9
 
Purity:≥99% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). Insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light. Keep under inert gas.
 
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Product Literature References

Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress: K.S. Lee, et al.; Thorax 71, 52 (2015), Application(s): Cell culture , Abstract; Full Text
TGF-β Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms: W.B. Fang, et al.; PLoS One 10, e0135063 (2015), Abstract; Full Text
In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas: P.A. Robe, et al.; Clin. Cancer Res. 10, 5595 (2004), Abstract;
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E: V. Petegnief, et al.; Neuroscience 104, 223 (2001), Abstract;
Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis: U. Koedel, et al.; J. Infect. Dis. 182, 1437 (2000), Abstract;
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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