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United States 

BAY 11-7082

NF-κB inhibitor
 
BML-EI278-0010 10 mg 87.00 USD
 
BML-EI278-0050 50 mg 349.00 USD
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Replaces Prod. #: ALX-270-219

Inhibitor of cytokine induced IκBα phosphorylation resulting thereby in a decreased expression of NF-κB and adhesion molecules. Potential anti-inflammatory agent.

Product Specification

Alternative Name:(E)-3-[(4-methylphenylsulfonyl]-2-propenenitrile
 
Formula:C10H9NO2S
 
MW:207.2
 
CAS:19542-67-7
 
Purity:≥99% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO, 100% ethanol, methanol or methylene dichloride; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light. Keep under inert gas.
 
ALX-270-219
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ALX-270-219

Product Literature References

Effect of Glutamate on Brain Iron Metabolism and the Regulation Mechanism: P. Yu, et al.; J. Drug Metab. Toxicol. 6, 190 (2015), Application(s): Cell culture , Full Text
Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages: D.K. Lee, et al.; FEBS Lett. 589, 2859 (2015), Application(s): Cell Culture, Abstract;
TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer: J.B. Jeong, et al.; Int. J. Mol. Sci. 16, 10411 (2015), Application(s): Cell Culture, Abstract; Full Text
Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death: T.M. Kauppinen & R.A. Swanson; J. Immunol. 174, 2288 (2005), Abstract; Full Text
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E: V. Petegnief, et al.; Neuroscience 104, 223 (2001), Abstract;
Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells: S.A. Keller, et al.; Blood 96, 2537 (2000), Abstract;
Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha- induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways: M.M. Remacle-Bonnet, et al.; Cancer Res. 60, 2007 (2000), Abstract;
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor- kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis: F. Thevenod, et al.; J. Biol. Chem. 275, 1887 (2000), Abstract; Full Text
Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997), Abstract; Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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