Online Purchasing Account You are logged on as Guest. Login Register a New Account Shopping cart (Empty)

PP1

Src kinase inhibitor



BML-EI275-0001	1 mg	114.00 USD

BML-EI275-0005	5 mg	472.00 USD
Do you need bulk/larger quantities?

Replaces Prod. #: ALX-270-177

A highly potent and selective inhibitor of Src family tyrosine kinases, IC₅₀=5 nM for p56^lck; p59^fynT=6 nM; p60^src=170 nM. Inhibition of Src family kinases by PP1 has been shown to: prevent a-thrombin-stimulated Akt phosphorylation, delay PAF-mediated STAT3 phosphorylation, block Zn²⁺-induced Ras activation, block adhesion-dependent tyrosine phosphorylation of p105^{HEF1 5}, and inhibit HLA-DR-induced tyrosine phosphorylation without affecting the activation of ERK1/2.

Product Details

Formula:	C₁₆H₁₉N₅

MW:	281.4

CAS:	172889-26-8

Purity:	≥98% (TLC)

Appearance:	Tan solid.

Solubility:	Soluble in DMSO (25mg/ml), slightly soluble in 100% ethanol.

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Use/Stability:	Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Regulatory Status:	RUO - Research Use Only

Please mouse over

Product Literature References

Novel inhibitors of microtubule organization and phragmoplast formation in diverse plant species: Y. Kimata, et al.; Life Sci. Alliance 6, e202201657 (2023), Abstract;

Gαs proteins Activate p72 Syk and p60-c-Src Tyrosine Kinases to Mediate Sickle Red Blood Cell Adhesion to Endothelium via LW-αvβ3 and CD44-CD44 Interactions: E. Chiou, et al.; Int. J. Biochem. Cell. Biol. 65, 40 (2015), Application(s): Cell Culture, Abstract;

α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation: S. Basu, et al.; J. Biol. Chem. 289, 3842 (2014), Abstract;

The specificities of protein kinase inhibitors: an update: J. Bain et al.; Biochem. J. 371, 199 (2003), Abstract;

The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases: L. Tatton et al.; J. Biol. Chem. 278, 4847 (2003), Abstract;

The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes: F. Carlomagno et al.; Cancer Res. 62, 1077 (2002), Abstract;

Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells: J. Geginat et al.; J. Exp. Med. 194, 1711 (2001), Abstract;

Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras: J. Abe et al.; J. Biol. Chem. 275, 1739 (2000), Abstract;

Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase: D.J. Osterhout et al.; J Cell Biol 145, 1209 (1999), Abstract;

Structural basis for selective inhibition of Src family kinases by PP1: Y. Liu et al.; Chem. Biol. 6, 671 (1999), Abstract;

The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells: H. Tang et al.; J. Biol. Chem. 273, 18268 (1998), Abstract;

Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors: T. Igishi & J.s. Gutkind et al.; Biochem. Biophys. Res. Commun. 244, 5 (1998), Abstract;

Src family-selective tyrosine kinase inhibitor, PP1, inhibits both Fc epsilonRI- and Thy-1-mediated activation of rat basophilic leukemia cells: M. Amoui et al.; Eur. J. Immunol. 27, 1881 (1997), Abstract;

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation: J.H. Hanke et al.; J. Biol. Chem. 271, 695 (1996), Abstract;